Many people suffer from muscular atrophy. This is often caused by neurological disorders. Muscles that do not receive nerve impulses to stimulate them to move are non-functional and gradually disappear. Spinal muscular atrophy is a very serious neurological disorder. This disease occurs in childhood and leads to a very rapid loss of muscle mass. Over time, the respiratory muscles are weakened and there are problems with breathing. Therefore, people who suffer from spinal muscular atrophy die young. A less dangerous but also annoying disease that will weaken the muscles is myasthenia and myasthenic syndrome. Neurological diseases require specialist treatment. Sometimes it is possible to relieve the symptoms significantly.
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Muscle atrophy also occurs in many other situations. They are often a consequence of long-term immobilization, cancer cachexia, complications of taking chemotherapeutics and the like. They are often accompanied by osteoporosis, i.e. reduced bone mineral density, which makes them prone to fractures. Such muscle atrophy can be treated with anabolic steroids, which stimulate muscle growth. Bisphosphonates are administered to osteoporosis, which stimulate the mineralization of the bone. Sarms, i.e. compounds that bind to the androgenic receptor, are also gaining in popularity. They show selective action in relation to this receptor. They have an anabolic but not androgenic effect. The best tested compounds include LGD-4033 and MK-677. They show positive effects on muscles as they support their growth. Moreover, they increase bone mineral density.
Sarms are used to treat muscle atrophy and osteoporosis, but also by bodybuilders and athletes who want to build high muscle mass and increase strength.